Endocrine Abstracts

Thyroid cancer remains the most common endocrine malignancy worldwide and its incidence and mortality has increased steadily over the last four decades. In general terms it has a good outcome, however, some patients develop aggressive forms of thyroid cancer that are untreatable and the molecular bases are poorly understood. These aggressive forms have lost NIS (Na/I Symporter) function, one of the most important hallmarks during thyroid cancer progression as it leads to radio...

Thyroid cancer remains the most common endocrine malignancy worldwide and its incidence and mortality has increased steadily over the last four decades. In general terms it has a good outcome, however, some patients develop aggressive forms of thyroid cancer that are untreatable and the molecular bases are poorly understood. These aggressive forms have lost NIS (Na/I Symporter) function, one of the most important hallmarks during thyroid cancer progression as it leads to radio...

The presence of differentiated follicular thyroid cells in thyroid cancer is critical for the antitumor response to radioactive iodide treatment, and loss of the differentiated phenotype is a key hallmark of iodide-refractory metastatic disease. Thus, one of the objective of our laboratory is to study the signals and molecular mechanisms involved in thyroid differentiation in cancer. Among genes responsible of thyroid differentiated phenotype are the transcription factor PAX8 ...

Cell differentiation occurs as a result of the concerted activation of multiple signalling pathways in response to environmental stimuli. We have stu died the role elicited by several growth factors and oncogenes in the control of Sodium/Iodide Symporter (NIS) gene expression, a thyroid differentiation marker. Our results have shown that IGF1/PI3K and TGFbeta/Smads inhibit NIS gene transcription induced by TSH/cAMP, a mechanism mediated by the inhibition of Pax8 binding to NIS...

Thyroid cancer derived from follicular cells is the most frequently endocrine malignancy with an increasing rate of incidence. The identification of new molecules involved in the pathogenesis of these tumors is necessary in order to use it as a novel targets for a better diagnostic and therapy. Recently, the RNA networks emerge as fundamental in the control of gene expression, achieving a strong interest the microRNAs (miRNAs). Our RNA-Seq study together with the analysis of T...

Introduction: Primary hyperaldosteronism (PH) is a cause of arterial hypertension (HT). The prevalence ranged from 1 to 15%. PH is associated with higher rates of cardiovascular morbidity and mortality. PH is under-diagnosed. The aims were to know the prevalence of PH, the clinical and hormonal profiles, outcomes, and prognosis of our population.Material and Methods: A retrospective review of patients with primary hyperaldosteronism in our hospital in th...

Background: Chromogranin A (CgA) is the most abundant granin in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). As a tumor marker is moderately sensitive and nonspecific. Meningiomas are benign brain tumors that are usually to recur. Studies have shown in vitro and in vivo that meningiomas, regardless of histology and classification, express somatostatin receptors (SSTRs). GA68-DOTATATE PET is an exciting imaging modality that has shown significant a...

The oncofoetal miRNA-binding protein LIN28B plays an important role in differentiation and cancer progression. Lin28B induces epithelial-mesenchymal transition, and it is considered as a bad prognostic marker in several tumours. The aim of this work was to study the effect and regulation of LIN28B on the thyroid cancer progression process. In a first approximation a miRNA targets computational predictions were performed with miRanda algorithm and we found that among others the...

Gerbil (Meriones unguiculatus) a non traditional laboratory model with reproductive state influenced by photoperiod, was used to analyze those photoperiodic mechanisms involving reproductive regulation. The 14:10 photoperiod has been widely used for reproductive research since 1950 (Everett). As is well known gerbils locomotor activity cycle has been reported to be crepuscular and reproductive cycle presents two annual peaks. As for the estrous cycle (EC), it has been...

Introduction: Obesity prevalence is growing every year. In most cases, origin is exogenous, a mixture of sedentary and overeating. However, some patients are trend to develop obesity caused by their genetics and other illness.Case report: A 62-year-old women with diabetes type 2, anxiety and osteoporosis was remitted to our center for obesity. She had been obese since childhood, with very low level of activity and snacking trend. On physical examination ...